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KMID : 0882420190940020159
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Korean Journal of Medicine
2019 Volume.94 No. 2 p.159 ~ p.169
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Vascular Calcification in Patients with Chronic Kidney Disease
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Jung Ji-Yong
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Abstract
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Cardiovascular morbidity and mortality are very common in patients with chronic kidney disease, which may result in part from vascular calcification. Vascular calcification requires osteoblastic trans-differentiation of vascular smooth muscle cells through an active and highly regulated process that is morphologically and functionally similar to bone formation in a number of ways. Multiple studies have been published on this topic, but the precise mechanism of vascular calcification remains unclear. This review presents recent insights into the mechanism of vascular calcification, as well as therapies that modulate mineral metabolism.
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KEYWORD
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Vascular calcification, Chronic kidney disease, Vascular smooth muscle, Trans-differentiation, Mineralization
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